Studies have revealed the ability of type I interferon IFN-cysus to fight Zika virus infection

Reporters learned from Nantong University, the university's Associate Professor Chen Jinling and the University of Texas Department of Medicine jointly published a study on
, revealed the type I interferon IFN-I resistance to Zika virus infection, for the infection of the Zika virus led to adverse pregnancy of pregnant women provide a theoretical basis for diagnosis and treatment.
adults infected with the Zika virus have no obvious symptoms or mild symptoms. But babies born to mothers with the Zika virus during pregnancy are not so lucky. The Zika virus is the only insect-borne virus known to pass through (or) infect the placenta, causing abnormal fetal development. Pregnant women infected with the Zika virus can cause abnormal fetal development, including spontaneous abortion, intraconsitive retardation and microcephaly.
Chen Jinling found in the study that fetal mouse type 1 interferon (IFN-I) has antiviral effects. She mated wild female mice with IFNAR-/- male mice to build a model of pregnant mice. Stillbirths were not observed in pregnant mice after contracting the Zika virus in the middle of pregnancy, and levels of the virus decreased significantly in the mother mice. In this model, the pregnant mice themselves lacked a type 1 interferon signal, but the fetal mice had a relatively complete IFN-I signal. This means that the IFN-I signal for fetal mice not only gives the mice their own resistance to the Zika virus, but also provides feedback to help the mother fight the Zika virus. In in-body culture, IFN-10 was found to significantly inhibit Zika virus replication, with the dual characteristics of type I interferon and leume cell interleton-10 family.
The study clarified the correlation between adverse pregnancy outcomes caused by the Zika virus and the time of infection, revealed the ability of IFN-0 to fight Zika virus infection, not only theoretically deepened the understanding of the mechanism of bad pregnancy caused by the Zika virus, but also proved in practice the protective effect of IFN-10 on the mother-child interface, providing a theoretical basis for the further use of IFN-1 to treat patients with Zika virus, especially pregnant women infected with Zika virus. (Source: Zhang Wei Xuling, Science and Technology Daily