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The reporter learned from Anhui Agricultural University that Professor Wan Xiaochun of the State Key Laboratory of Tea Biology and Resource Utilization (Anhui Laboratory) of the university, and the research group of Professor Shen Yong of the University of Science and Technology of China, found that green tea can prevent and delay 5XFAD genetic modification.
The formation of β-amyloid (Aβ) in the mouse brain reduces the damage of nerve synapses and improves the ability of learning and memory
.
The main results of the study were published online recently in the journal Molecular Nutrition and Food Research
With the aging of the population, neurodegenerative diseases represented by Alzheimer disease (AD) are showing a rapid and high incidence trend
.
Researchers used green tea extract (GTE) to intervene in human-derived amyloid precursor protein (APP) and presenilin (PS1) double transgenic 5XFAD mice, and found that GTE was significantly reduced under the same amount of human daily tea consumption.
The content of Aβ in the mouse brain and reduce the expression of APP cleavage products; at the same time, GTE can reduce the excessive activation of glial cells, enhance the expression of synaptic marker proteins, and reduce the neurotoxicity caused by Aβ; behavioral tests further prove that GTE intervention is significant Improved the cognitive ability of 5XFAD mice
.
In addition, transcriptome sequencing results suggest that the above effects may be related to the regulation of stress and immune-related gene expression by GTE
This research shows that green tea may prevent and delay Alzheimer's disease, and provides a theoretical basis for elucidating the mechanism of tea drinking to prevent AD and further transformation and application
.
(Reporter Wu Changfeng)
