Studies do not support the treatment of new crown infections with hydroxychloroquine and chloroquine

study, published online July 22 in nature, found no significant antiviral effects of chloroquine and hydroxychloroquine on new coronavirus infections in macaques or human lung cells.
hydroxychloroquine and chloroquine are commonly used to treat malaria, and more than 80 registered clinical trials have investigated their potential to treat new coronavirus. Previous studies have found that these two drugs can suppress new coronavirus infections in cell culture, but their effectiveness in treating new coronary infections has been controversial.
Roger Le Grand of the University of Paris-Sakre, France, and the CEA Institute for Biomedical Imaging, France's National Institute of Health and Medical Research, and colleagues studied the therapeutic effects of hydroxychloroquine on crab-eating macaques, a non-human primate model that simulates a new human coronavirus infection. The results showed that hydroxychloroquine showed no significant antiviral activity, either before, shortly after infection, or after a long period of infection. In addition, the use of this antimalarial drug in association with the antibiotic azithromycin did not have a significant effect on the viral levels of crab-eating macaques.
in another study, Stefan Pohlmann of the Leibnitz Institute for Primates, a German primate research centre in Gottingen, and colleagues found that chloroquine had no antiviral activity against the new coronavirus in human lung cells. They explained that in previous experiments, cells used to demonstrate the positive effects of chloroquine lacked an enzyme commonly found in lung cells that promotes the entry of new coronavirus into human lung cells. The authors stress that studies to assess the drug activity of the new coronavirus should use cell line that can simulate lung tissue.
, these two studies do not support the use of hydroxychloroquine and chloroquine to treat new crown infections. (Source: Feng Lifei, China Science Journal)
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