Stroke: There is a positive correlation between the occurrence of wave protein and stroke

VIM (vimentin) wave protein is a kind of cytostic skeleton intermediate silk protein, which plays an important role in intracellular dynamics and structure.
it is expressed on the surface of different cell types and secreted by endodertic cells, active macrophages, and astrocytes into the extracellular environment.
VIM is involved in a wide range of cellular functions, including differentiation, adhesion, migration, signal transduction, and apoptosis.
, it has received a lot of scientific attention in the development and metastasis of cancer and has been associated with many other pathophysiological conditions, such as cataracts, Crohn's disease and rheumatoid arthritis.
recent studies have shown that VIM is associated with the development of atherosclerosis.
a study of patients with coronary artery disease and a healthy control group reported higher levels of VIM in the serum of patients with coronary artery disease, and positive correlation between VIM levels and the number of lesions of coronary arteries.
In addition, studies have shown that recombination of VIM injections in the abdominal cavity of mice can induce atherosclerosis and promote inflammatory expression in aortic tissue, and various inflammatory effects of VIM have been reported.
, viM binds to the promoter of 12/15-lipooxygenase and regulates its activity, which in turn induces endothystic inflammation.
VIM can also induce macrophages to secrete inflammatory cytokines, which may promote arterial inflammation.
although there are several possible links between VIM and atherosclerosis, which is one of the main causes of stroke, it is not clear whether VIM is associated with the rate of stroke.
, jun Xiao of Lund University in Sweden, and others, based on Malm. Diet and Cancer Cohort, which explore the relationship between VIM and an increased incidence of stroke.
their prospective study data from between 1991 and 1994, data were collected from 4,688 participants (39.7 per cent male; average age 57.6 years) and blood samples were taken.
the risk of stroke were tracked until 2018.
the relationship between VIM and stroke by using Cox regression.
results showed that a total of 528 subjects were diagnosed with stroke during an average follow-up of 22.0 years, of whom 434 were ischemic strokes.
after adjusting for potential confumeruous factors, participants with a maximum quarterile (vs 14th quarter) had a 1.34 times higher overall stroke risk (95% CI, 1.03-1.74) and a 1.47 times higher risk of ischemic stroke (95% CI, 1.10-1.98).
the occurrence of total stroke and ischemic stroke were significantly affected by cervical arterial plaques and VIM (P-0.041 and 0.011, respectively).
participants with cervical arterial plaques were more associated with stroke, especially the risk of ischemic stroke (adjusted risk ratio, 1.66).
significance of this study is that the discovery of a positive correlation between VIM and the rate of stroke, especially in individuals with cervical arterial plaques, may require more similar studies to confirm their observations.
original origin: Xiao, J., Chen, L., Melander, O., Orho-Melander, M., Nilsson, J., Borné, Y., samp; Engström, G. (2021). Circulating Vimentin Is Associated With Future Incidence of Stroke in a Population-Based Cohort Study. _Stroke_, STROKEAHA-120. Freeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not reproduced by any media, website or individual without authorization, and are authorized to be reproduced with the words "Source: Mets Medicine".
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