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Whether high-density lipoprotein (HDL) is associated with the risk of vascular brain injury is unclear
.
HDL is composed of many kinds of apolipoproteins, forming different HDL subtypes
Blood vessel
Recently, a research article was published in Stroke, an authoritative journal in the field of cardiovascular diseases.
Researchers used sandwich ELISA to determine the CHS (Cardiovascular Health Research) participants collected during 1998/1999 (average age was 80 years old) HDL subspecies in plasma
.
In cross-sectional analysis, participants with higher plasma levels of apoA1 and lower levels of apoE in HDL were less likely to develop infarcts as determined by concealed MRI: the ratio of apoA1 levels Q4 to Q1 was 0.
68 (95% CI was 0.
50 -0.
93), the ratio of the apoE level Q4 to Q1 is 1.
36 (95% CI 1.
01-1.
84)
.
Similarly, in prospective analysis, the apoA1 level in HDL subtypes lacking apoC3, apoJ or apoE was negatively correlated with recessive infarction, and the apoE level in HDL subtypes lacking apoC3 or apoJ was directly related to recessive infarction
In contrast, the concentrations of apoA1 and apoE in the HDL complementary subtypes containing these aposs are not associated with recessive infarction
.
The pattern of association between clinically significant ischemic stroke and HDL subtypes of apoA1, apoE and apoA1 and apoE is similar to that observed for recessive infarction, but not as significant
Stroke
Thus, this study emphasizes that HDL subspecies determined by apolipoprotein content can be used as relevant biomarkers for recessive and dominant vascular brain damage
.
.
Original source:
Original source:Manja Koch.
HDL (High-Density Lipoprotein) Subspecies , Prevalent Covert Brain Infarcts, and Incident Overt Ischemic Stroke: Cardiovascular Health Study in this message
