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Despite the lack of evidence to prevent relapse cardiovascular disease, statins are often only used in ischemic stroke patients 80 years of age and older.
, researchers looked for evidence of prescriptions for the oldest statins, according to a study published recently in the leading journal of cardiovascular disease.
researchers conducted a retrospective queuing study of hospitalized patients aged 65 and older who had first ischemic stroke between 1999 and 2016 and did not use statins.
researchers included patients between the ages of 65 and 80 and compared them with the latest evidence of the efficacy of statins.
outcome of the study was a compound endpoint of stroke recurrence, myocardial infarction, and cardiovascular mortality.
secondary outcome is all death.
researchers used Cox models that changed over time to explain changes in prescriptions for statins over time.
researchers compared statin prescriptions for at least 2 years with those who were not treated and prescribed for 2 years.
the analysis for potential confuse factors, the researchers calculated the number of people in need of treatment based on the adjusted risk ratio and corrected the number of deaths two years before follow-up.
the study included 509,000 patients aged 65 and over, of whom 3,157 were aged 80 and over.
The use of statins for 2 years in patients aged 80 and over reduces the risk of compound endpoints (adjusted risk ratio of 0.80 (95% CI is 0.62-1.02)) and all-cause mortality (adjusted risk ratio of 0.67, 95% CI is 0.57-0.80).
The corrected mortality rate for patients in the two years before statin use was 23.9 per cent, and during the 3.9-year period for the medium follow-up period, 64 people needed treatment for major outcomes and 19 for all-cause deaths.
, it can be seen that patients aged 80 and over who are hospitalized for ischemic stroke and discharged from hospital with statin medication are associated with a decrease in cardiovascular events.
