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Stroke: The dose-response relationship between long-term blood pressure variability and cognitive decline

 Last Update: 2021-08-01
 Source: Internet
 Author: User

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Recently, the heart blood vessels published on the prestigious journal Stroke the areas of disease research article, the researchers aimed to assess whether higher long-term blood pressure variability associated with accelerated cognitive decline, and assess their potential dose-response relationship
.

Heart blood vessels

The researchers used original survey data from the Health and Retirement Study and the Longitudinal Study on Aging in the UK
.

The standardized Z score of cognitive function is the main outcome indicator

Researchers used the standard deviation of visit blood pressure, coefficient of variation, and variance independent of the mean for analysis, and applied linear mixed models and restricted splines to assess the correlation and explore dose response patterns
.

Piecewise regression is used to analyze the dose-response relationship and estimate the turning point

The study included 12,298 participants without dementia (mean age: 64.
6 ± 8.
6 years)
.

Researchers observed a significant association between blood pressure variability and cognitive decline

It can be seen that the higher long-term blood pressure variability in adults over 50 years old is associated with accelerated decline in cognitive ability, and has a non-linear dose-response relationship
.

Further randomized controlled trials are needed to evaluate the potential benefits of strategies to reduce blood pressure variability from a cognitive health perspective

Higher long-term blood pressure variability in adults over 50 years of age is associated with accelerated decline in cognitive ability, and has a non-linear dose-response relationship

Original source:

Chenglong Li.

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