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Often patients will see such diagnoses or imaging reports as "lacunar infarction", "multiple cerebral infarction", "ischemic demyelination", "leukoaraiosis", "leukoencephalopathy", etc.
But that's often wrong, because that's what we're going to talk about here -- cerebral small vessel disease, which is a big problem with small lesions
Cerebral small vessel disease is a big problem with small lesions
Among them, progressive white matter changes (WMCs) are the most prominent features of small cerebral vessels
In a multicenter, double-blind, randomized controlled trial, researchers randomly assigned participants with moderate or severe WMCs and at least one lacunar infarction detected on brain MRI in a 1:1 ratio to cilostazol azole and aspirin group
Between July 2013 and August 2016, 256 participants were randomly assigned to cilostazol (n=127) and aspirin (n=129)
At 2 years, WMC volume as a percentage of total WM volume and WMC volume as a percentage of intracranial volume increased in both groups, but neither analysis showed significant differences between groups
The peak height of the MD histogram in normal-appearing WMs was significantly lower in the aspirin group compared with the cilostazol group
Compared with aspirin, cilostazol significantly reduced the risk of ischemic vascular events (0.
In conclusion, there was no significant difference in the effects of cilostazol and aspirin on WMC progression in patients with cerebral small vessel disease
references:
Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial.
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