Stroke: Premature babies, are they more likely to have a stroke in adulthood?

 

The incidence of preterm birth (gestational age less than 37 weeks) worldwide is close to 11%, affecting 15 million newborns each year
.

Among preterm infants receiving modern neonatal and pediatric care, more than 95% of preterm infants can now survive to adulthood, so their long-term health status is increasingly important in clinical and public health

According to reports, adult survivors of preterm birth have an increased risk of hypertension, diabetes , hyperlipidemia, and ischemic heart disease, which are major risk factors for stroke
.

However, their long-term stroke risk is rarely studied, and the results of the study are not the same

diabetes

Because stroke is the leading cause of death and disability worldwide, there is a need to better understand the risk of stroke to guide the growing number of survivors of preterm infants in the long-term clinical care and prevention
.

prevention

Studies have found that premature delivery is related to increased stroke morbidity or mortality in adulthood
.

However, the inconsistent results of previous studies may be related to some methodological issues, including small sample size, insufficient follow-up in adulthood, or possible survivor bias in the earliest birth cohort

Most studies fail to assess the risk of specific major stroke types (hemorrhagic or ischemic)
.

In addition, it is unclear whether the previously reported association is due to confusion caused by the common family (genetic or environmental) determinants of preterm birth and stroke, rather than a direct effect of preterm birth

Stroke In addition, it is unclear whether the previously reported association is due to confusion caused by the common family (genetic or environmental) determinants of preterm birth and stroke, rather than a direct effect of preterm birth

(2) Explore whether these associations change due to gender, fetal growth or birth year;

(3) Use co-sibling to assess the potential confounding of common family (genetic or environmental) factors
.

Core hypothesis: Preterm birth is associated with increased risk of stroke and its main types in adulthood, and these associations are largely independent of common family factors
.

Based on a national cohort, they studied all 2,140,866 single births born in Sweden from 1973 to 1994 and survived to the age of 18.

These people's first stroke was followed up to 2015 (the maximum age is 43 years)

Result
.

The adjusted risk ratio for stroke associated with preterm birth (<37 weeks) was 1.

Ischemic stroke (early preterm birth: adjusted hazard ratio, 1.
33 [95% CI, 0.
87-2.
03]; any preterm birth: 1.
31 [1.
07-1.
60]) has a positive correlation
.

These findings are similar in men and women, and can only be partially explained by the common determinants of preterm birth and stroke in the family
.

These findings are similar in men and women,

In this large national cohort, preterm birth is associated with an increased risk of hemorrhagic and ischemic stroke in adulthood
.

Survivors of preterm birth require early preventive evaluation and long-term clinical follow-up to reduce their lifetime risk of stroke
.

Preterm birth is associated with an increased risk of hemorrhagic and ischemic stroke in adulthood
.

Original Source:
Crump C, Sundquist J, Sundquist K.
Stroke Risks in Adult Survivors of Preterm Birth: National Cohort and Cosibling Study.
Stroke.
2021;52(8):2609-2617.
doi:10.
1161/STROKEAHA.
120.
033797

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