Stroke: Post-traumatic stress disorder, antidepressants, and hemorrhagic stroke

Antidepressants are commonly used for post-traumatic stress disorder (PTSD) and may increase the risk of bleeding, including hemorrhagic stroke.
, researchers looked at the effects of PTSD, selective 5-serotonin, and epinephrine reuptake inhibitors (SSRI and SNRI) on the risk of haemorrhagic stroke in 1.1 million young Chinese veterans, according to a study published recently in the authoritative journal Cardiovascular Disease.
-time multiple Cox model was used to assess the risk of hemorrhagic stroke measured by PTSD status and SSRI or SNRI use, while adjusting demographic indicators, lifestyle factors, stroke, and psychosis.
13 years of follow-up (an average of 2.14 years), 507 patients (12 per cent of women) had hemorrhagic stroke.
rate of 1.70 incidents per 10,000 people per year.
in unrealed models, PTSD was associated with an 82% increase in the risk of new blood stroke (risk ratio of 1.82 (95% CI is 1.48-2.24)), and the use of SSRI was more than 2 times higher (HR is 2.02 (95% CI is 1.66-2.57), while the use of SNRI is associated with a 52% increase in risk (HR is 1.52 (95% CI is 1.08-2.16).
in a fully adjusted model, the effects of PTSD and SNRI decreased (adjusted HR of 1.03 (95% CI is 0.81-1.34) and adjusted HR was 1.19 (9) 5% CI is 0.83-1.71), but the use of SSRI is still associated with a 45% increase in the risk of hemorrhagic stroke (corrected HR is 1.45 (95% CI is 1.13-1.85).
, drug and alcohol abuse are also associated with an increased risk of stroke.
and non-Hispanic are protective factors.
in sensitivity analysis, health care utilization is a small but important indicator of stroke.
, it can be seen that the use of SSRIs is associated with stroke, and PTSD and SNRI are not related to it.
, while pursuing other changeable risk factors and non-drug treatment of PTSD is still critical, SNRI may be more suitable for the treatment of PTSD and co-merger.
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