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Stroke: Patients with symptomatic carotid plaque are characterized by increased expression of xanthine oxidase

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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Xanthine oxidase (XO) is a key enzyme of uric acid metabolism and is considered to be an oxidation pathway that promotes the progression of atherosclerotic plaques, but its role in plaque instability has not yet been elucidated
.

Recently, the heart blood vessels published a research article on the disease areas authoritative journal Stroke, the researchers assumed that the expression of XO and cardiovascular risk factors in patients with symptomatic carotid artery plaques
.

Heart blood vessels

The asymptomatic patients were stratified, researchers obtain carotid atherosclerotic plaques from 44 cases of symptomatic patients and 44 patients without ischemic cerebrovascular events in patients, by immunological staining XO detect the expression of proteins, And compare the percentage of cells expressing XO and CD68 (macrophage marker) between each group
.

The researchers also measured the participants' biochemical and demographic cardiometabolic risk factors

immunity

Compared with patients with asymptomatic plaques, carotid atherosclerotic plaques in symptomatic patients were significantly associated with increased XO expression (median [interquartile range]: 1.
24 [2.
09] vs 0.
16 [0.
34]; P< 0.
001), and the level of uric acid in the circulation increased significantly (mean±SD: 7.
36±2.
10 vs 5.
37±1.
79 mg/dL; P<0.
001)
.

In addition, XO expression in carotid atherosclerotic plaques was negatively correlated with serum high-density lipoprotein cholesterol levels (P=0.

cholesterol

It can be seen that XO overexpression in macrophages is associated with increased serum uric acid and decreased high-density lipoprotein cholesterol levels, and may have a potential role in unstable carotid plaques

XO overexpression in macrophages is associated with increased serum uric acid and decreased high-density lipoprotein cholesterol levels, and may have a potential role in unstable carotid plaques

Original source:

Morsaleh Ganji.

Carotid Plaques From Symptomatic Patients Are Characterized by Local Increase in Xanthine Oxidase Expression in this message

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