Stroke: DNA content in blood clots can help identify heart-caused stroke cases contained in unexplained embolism.

Determining the cause of acute ischemic stroke (AIS) is critical to guiding secondary prevention.
previous studies have found inconsistent results on possible correlations between AIS earlier causes and thrombosis components assessed by semi-quantitative histological analysis.
recently, a study published in Stroke, an authoritative journal in the field of cardiovascular disease, analyzed the correlation between AIS causes and AIS thrombosis cell composition and content composition, and evaluated them using quantitative biochemical analysis.
the researchers mechanically abrasively prepared samples of 250 plasma thrombosis in AIS patients, and estimated the levels of platelets, red blood cells, and white blood cells in thrombosis patients by quantifying GP (glycoglobin) VI, hemoglobin, and DNA levels in AIS patients.
according to the TOAST classification (ORG10172 trial in acute stroke treatment), AIS eel causes are classified as heart-caused, non-heart-caused or unexplained embolism stroke.
had higher DNA content in the heart-sourced stroke bolt than non-heart-sourced stroke thrombosis (35.8 vs. 13.8 ng/mg, P.lt;0.001), while GP VI levels were lower (0.104 vs. 0.117 ng/mg, P.045).
subjects who distinguished between heart-sourced and non-centrist hydrants by DNA content had an area of 0.72 (95%CI was 0.63-0.81).
if the DNA threshold in the thrombosis is set at 44.7 ng/mg, 47% of unexplained thrombosis will be classified as a heart-sourced thrombosis with a specificity of 90%.
it can be seen that the DNA content in blood clots may be an accurate biomarker used to identify cases of heart-caused stroke in patients with unexplained embolism AIS.
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