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Cell-free DNA (cfDNA) and endogenous deoxyribonuclease activity are opposing mediators that may influence the inflammatory response after acute ischemic stroke
.
In this cohort study, researchers investigated the relationship between these markers, circulating inflammatory mediators, and the clinical course, including stroke-related events in acute stroke patients.
infection (SAI)
.
Between March 2018 and August 2019, Hannover Medical School prospectively recruited 92 stroke patients who underwent mechanical thrombectomy
for large vessel occlusion .
Deoxyribonuclease activity, cfDNA, damage-associated molecular patterns, and circulating cytokines were measured in venous blood collected before mechanical thrombectomy and immediately after 7 days
thrombus
Patients with poor clinical outcomes had higher cfDNA concentrations
.
After adjusting for confounding factors (Essen Stroke Risk Score, NIH Stroke Scale, and gender), 7-day cfDNA levels were independently associated with clinical outcomes, especially mortality (adjusted odds ratio 3.
Thus, the interaction of endogenous DNase activity and cfDNA in acute stroke requires interesting new diagnostic and potential therapeutic approaches
.
We confirm an independent association of cfDNA with the deleterious clinical course of stroke due to large vessel occlusion
The interaction of endogenous DNase activity and cfDNA in acute stroke requires interesting new diagnostic and potential therapeutic approaches
Original source:
Gerrit M.
