Stroke: Bleeding removal capacity in neonatal cerebrospinal fluid is associated with hydrocephalus

The risk of hydrocephalus and adverse neurological prognosis increased in premature infants after hemorrhageIron is associated with ventricular enlargement, hippocampus injury and poor prognosis after IVHIn a recent study published in the journal Stroke, an authoritative journal on cardiovascular disease, the researchers hypothesized that levels of cerebrospinal fluid blood breakdown products and endogenous iron removal proteins in IVH newborns differ from those of post-hemorrhagic iVH newbornsresearchers assessed premature babies born with an average birth age of less than 30 weeks, who received waist circumsties for clinical evaluation at an average of 2 weeks after birthEach group included the control group (n-16), low-level IVH (I-II; n-4), high IVH (III-IV; n-6) and post-hemorrhagic hydrocephalus (n-9)The control was a premature baby born at 30 weeks of pregnancy, with no brain abnormalities or intracranial bleeding, and they had a waist-down wear for clinical treatmentThe researchers measured cerebrospinal fluid hemoglobin, total bilirubin, total iron, ferritin, copper blue protein, transferritin, touch beadsin, and hemoglobin levelsincreased bloodheprotein levels in patients with cerebrospinal fluid after hemorrhage (9.45 vs6.06 ?g/mL, P 0.05) compared to high-level IVH children, and increased levels of cerebrospinal thotin in children with hydrocephalus after hemorrhagic hydrocephalus (511.33 vs67.08, P 0.01)There were no significant inter-group differences in blood breakdown and iron-treated proteins for other cerebrospinal fluidsThe researchers observed a positive correlation between ventricular enlargement (egratio ratio) and ferritin (Pearson r-0.67), hemoglobin (Pearson r-0.68) and total bilirubin (Pearson r-0.69)thus shows that the hemoglobin level spree levels of newborns with hydrocephalus after bleeding are significantly higher than in high-level IVH newbornsLevels of blood breakdown products, hemoglobin, ferritin and bilirubin are associated with ventricle sizeSeveral removal strains in neonatal cerebrospinal fluid after blood loss did not rise, indicating that hydrocephalus after hemorrhagic deficiency is a disease state because of endogenous iron removal mechanism disorders