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The effect of mechanical thrombectomy (MT) on the functional outcome of acute ischemic stroke is highly time-dependent
In patients with thrombotic stroke that appeared 7.
However, recent randomized clinical trials have shown that MT may be very effective within 24 hours of onset
Although the results are encouraging, such automated software tools are not available in every stroke center
In addition, the patient groups in these trials are strictly screened, and strict inclusion may not be representative of the real-world environment
Quantitative lesion net water uptake (NWU) is a CT-based imaging biomarker and has been described as a useful tool for identifying patients within the thrombolytic time window
Lesion area water intake (Lesion water uptake) reflects the signs of acute infarction - Vascular edema, and provides insight into the rate of progress of the infarction, which is known to vary
Blood vessel
In fact, Minnerup et al.
However, the inter-individual variability of NWU increases with the time from onset to imaging, indicating that the rate of infarction progression is different
However, higher levels have been shown to be a predictor of the ineffectiveness of endovascular treatment, which is in turn associated with poor functional outcomes
In this way, Gabriel Broocks and others of the University of Hamburg, Germany, explored the prognostic value of NWU in patients treated with MT within 24 hours after the onset of symptoms
A total of 122 patients met the inclusion criteria
The multivariate prediction model including the above parameters produced the highest diagnostic ability in the classification of functional outcomes , with an area under the curve of 0.
diagnosis
When diagnosing patients with ischemic stroke that occur within an extended time window, the implementation of quantification of lesion water absorption as an imaging biomarker may improve clinical prognosis
Original source:
Broocks G, Kemmling A, Teßarek S, et al.
Quantitative Lesion Water Uptake as Stroke Imaging Biomarker: A Tool for Treatment Selection in the Extended Time Window? Stroke.
Published online September 20, 2021.
doi:10.
1161/STROKEAHA.
120.
033025
Quantitative Lesion Water Uptake as Stroke Imaging Biomarker: A Tool for Treatment Selection in the Extended Time Window?
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