STC2: a universal tumor biomarker and potential therapeutic target

STC2 is a glycoprotein widely expressed in various tumor cells and tumor tissues such as breast, colorectum, stomach, esophagus, prostate, kidney, liver, bone, ovary, and lu.

Importantly, STC2 also promotes the development of acquired resistance to chemotherapy and radiation thera.

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Recently, researchers from Tianjin Medical University Cancer Institute and Hospital published an article entitled "Stanniocalcin 2 (STC2): a universal tumor biomarker and a potential therapeutical target" in the journal J Exp Clin Cancer R.

Human STC2 is a protein composed of 302 amino acids, and Aa1-24 is the signal peptide for endoplasmic reticulum transpo.

STC2 is overexpressed in multiple types of human breast cancer tumors

STC2 is co-expressed with ER in breast cancer cell lines and sampl.

Transcription factors involved in STC2 regulation

ATF4 plays a key role in mediating the integrated stress response (IRS), and ATF4 is closely related to the expression of STC The tumor microenvironment is characterized by imbalanced oxygen levels, inadequate nutrient supply, and low pH; these stressful conditions lead to endoplasmic reticulum stress, disrupt protein maturation, accumulate unfolded or misfolded proteins, and ultimately activate evolutionarily conserved responses , Unfolding Protein Response (UP.

The biological role of STC2 in human tumors

The growth of tumors depends on the ability of tumor cells to proliferate and resist cell dea.

Biological functions of STC2 under hypoxic conditions

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In conclusion, STC2 is a promising biomarker for assessing patient prognosis and a potential candidate for the development of targeted therapy, especially for patients with advanced disease who often require combination thera.

references

Shuo Qie et .