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It should not be surprising that astronauts turn to various drugs to relieve symptoms caused by microgravity
Recently, in order to clarify this problem, a group of scientists from Beijing Institute of Technology studied the effect of microgravity on p-glycoprotein (P-gp), which is an important efflux transporter
P-glycoprotein is an atp-dependent efflux pump that can expel foreign bodies from cells
The researchers used a commonly used model to understand the effect of simulated microgravity (SMG) on P-gp in rats
The team first conducted experiments to determine the expression level of P-gp and the efflux function of P-gp
Considering that most astronauts report taking drugs with P-gp substrates, it may be necessary to clarify the role of P-gp and its interacting proteins in a microgravity environment in order to maintain their health in future missions.
There are still many questions to be clarified about how long-term microgravity affects our bodies
refer to
DOI: https://doi.
