South China Botanical Garden "use of Acorus tatarinowii extract in the preparation of drugs for the treatment of Alzheimer's disease" won the national invention patent

On October 17, it was learned that the "use of Acorus tatarinowii extract for the preparation of drugs for the treatment of Alzheimer's disease" completed by Chen Feng, researcher of South China Botanical Garden, Chinese Academy of Sciences was granted the national invention patent (Patent No.: zl201210453882.8) Alzheimer's disease is called Alzheimer's disease It is a fatal neurodegenerative disease with progressive development Its clinical manifestations are continuous deterioration of cognitive and memory functions, progressive decline of daily living ability, and various neuropsychological symptoms and behavioral disorders According to the survey results released by China Alzheimer's Association in 2011, there are about 36.5 million people suffering from dementia in the world, and one person suffers from this disease every seven seconds, with an average life span of only 5.9 years, which is one of the "four killers" threatening the health of the elderly At present, there are mainly cholinesterase inhibitors, cerebrovascular dilators, calcium antagonists, a β deposition inhibitors, α - secretase agonists, β - secretase inhibitors, γ - secretase inhibitors and regulators in the treatment of Alzheimer's disease Most of these drugs are chemical synthetic drugs or peptide drugs Due to the side effects of some chemical synthetic drugs in the long-term use, the disadvantages of peptide drugs, such as low oral bioavailability, easy to be hydrolyzed in vivo, poor selectivity, large molecular weight and difficult to pass through the blood-brain barrier, make their research face a huge challenge This provides a good opportunity for developing research on drugs that have anti Alzheimer's disease activity from natural products and Chinese herbal medicines Shi Changpu has important application prospects for the study of molecular mechanism of anti Alzheimer's disease in traditional Chinese medicine Acorus calamus is a species of Acorus calamus, which grows in wetlands or streams It is mainly distributed in various provinces in the south of the Yellow River Its rhizome is used as medicine, which has the functions of aromatization and moistening, opening the orifices and eliminating phlegm, awakening the mind and benefiting the intellect It is widely used in amnesia, apoplexy and aphasia, tinnitus, senile dementia and other diseases The invention provides the use of Acorus tatarinowii extract for the preparation of drugs for the treatment of Alzheimer's disease The extract is composed of the first part of the extract and the second part of the residue extracted by organic solvent through the ultrasonic extraction and cation exchange resin analysis steps, wherein the ultrasonic extraction solvent is water, the ultrasonic frequency is 30-40 kHz, and the cation exchange resin is used for the extraction The analytical solution of the resin column is sodium hydroxide aqueous solution and hydrochloric acid The organic solvents are petroleum ether, ethyl acetate and n-butanol The Acorus tatarinowii extract provided by the invention has excellent effect as the use of preventing and treating Alzheimer's disease, and has obvious effect of preventing and treating Alzheimer's disease Compared with other conventional methods, the method for obtaining Acorus tatarinowii extract in the use also has excellent effect.