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    Home > Medical News > Medical Research Articles > Sorbitol Special shortens the drying time of softgels by 40%?

    Sorbitol Special shortens the drying time of softgels by 40%?

    • Last Update: 2021-09-10
    • Source: Internet
    • Author: User
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    The soft capsule dosage form is favored by consumers because of its advantages such as good bioavailability, drug stability, accurate dosage, convenient eating, and good safety and sealing


    In this test, capsules containing sunflower oil (typically hydrophilic oil as a filler) were evaluated by mixing Sorbitol Special and glycerin at a 50:50 ratio as a plasticizer


    1.


    The capsule material undergoes a 17-hour gelation process to reach a viscosity of about 8k-10k cps






    2.


    The combined application of glycerin and Sorbitol Special 50:50 can make the capsule reach the target hardness faster than when glycerin is used alone


    Sorbitol sorbitan solution plasticizer

    This experiment investigated theplasticizer performance of SorbitolS pecial ® MDF 85 and competitor P in pure PEG filled (typically hydrophilic filled) capsules






    Plasticizer


    20


    water


    40

    1.
    Test methods and materials

    The capsule material undergoes a 17-hour gelation process to make its viscosity between 9k-11k cps
    .
    The gelatin glue is hydraulically pressed to a thickness of about 0.
    85mm, 12 drops (1 drops=0.
    0616ml, 12 drops about 0.
    74ml) oval, and sealed at 36.
    5°C
    .
    Under the conditions of 23°C and 30%RH, a drum dryer was used for preliminary drying for 60 minutes
    .
    The tray drying method is used, and the secondary drying is carried out at 20°C and 20%RH for 72 hours
    .
    Hardness is used to indicate the end of drying
    .
    Assuming that the target hardness of 20N, MDF 85 to achieve the target hardness faster than competing products P 33%
    .
    The drying time of the formula in this case is significantly faster than the commercially available filling containing water/potassium hydroxide and API
    .
    A formula that contains no water in the filling can increase the drying speed of the soft capsule
    .
    In all cases, for direct comparison, Sorbitol Special can increase the drying speed
    .




    Figure 2 Comparison of capsule hardness over time

    2.
    Conclusion

    For formula models with oil and PEG as fillers, Sorbitol Special plasticizer (used alone or in combination with glycerin) can significantly reduce drying time and beat competitors
    .
    For customers, using this product as a plasticizer can produce more capsules at a faster speed, thereby improving production efficiency and corporate profits, and helping customers to better win the market
    .


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