-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Researchers at Massachusetts General Hospital (MGH) found that an olfactory receptor gene that helps the sense of smell may also play a role in the metastasis of breast cancer to the brain, bones and lungs
"The prevailing view is that the only role of olfactory receptors, which transmits nasal cavity and sensory data to the brain, is to recognize smells and tastes," said Bakhos Tannous, Ph.
Breast cancer is the second most common malignant tumor after lung cancer and the main cause of cancer in women
"The olfactory receptor gene family is in various cancers, including prostate cancer, melanoma, lung and liver, although its role in breast cancer has replaced the past," said Dr.
"This activation converts a wide range of extracellular signals into intracellular information through the NF-κB/STAT signaling pathway, leading to cell proliferation, invasion and metastasis," explained Li Mao, the first author of the study and a graduate student in the experimental treatment unit
Future research may also lead to molecular inhibitors of OR5B21 in response to the team’s findings that downregulation of olfactory receptors resulted in a significant reduction in cancer cell metastasis
Tannous is an associate professor of neurology at Harvard Medical School and a neurologist at MGH
Article title
Olfactory receptor 5B21 drives breast cancer metastasis
