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Small molecules with dual functions

 Last Update: 2021-10-22
 Source: Internet
 Author: User

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The human intestine is a multi-species habitat that can control our health and happiness
.

Bacteria, viruses, and microbial fungi are part of this complex microbial community, helping us digest and immune defense

The core of this mechanism is a small ribonucleic acid (sRNA) and a small protein
.

Professor Kai Papenfort explained: “Small RNAs and small proteins were often overlooked in the past, but they play an important role in the physiology of microorganisms

Ribonucleic acid interferes with the metabolism of cholera pathogens at two different levels

In their paper, Papenfort and his team demonstrated that an RNA molecule called VcdRP (Vibrio cholerae double RNA and protein) can interfere with the metabolism of the cholera pathogen at two different levels, thereby controlling its harmful effects
.

"On the one hand, the sRNA molecule in VcdRP inhibits the production of cholera toxin

"Our research shows that the production of toxins and the pathogenic properties of cholera bacteria are directly related to its metabolism," Papenfort said
.

For the first time, researchers were able to identify sRNAs with this dual function in cholera bacteria

references:

Venkat K, Hoyos M, Haycocks J, Cassidy L, Engelmann B, Rolle-Kampczyk U, von Bergen M, Tholey A, Grainger DC, Papenfort K.

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