Significant progress! Research finds a new way to avoid the deadly inflammation of COVID-19!

May 27, 2020 /
Bio-ValleyBIOON /- Severe COVID-19 disease can cause excessive inflammation throughout the body, including the lungs, heart and brainMolly Gilligan, a student at the University of Minnesota's Twin Cities campus, recently published an article in the journal Cancer and Metastasis Reviews, studying the body's strong inflammatory response to the SARS-CoV-2 virus, which is now considered an iconic symptomAccording to the report, controlling the body's inflammatory response to SARS-CoV-2 may be as important as antiviral therapy or potential vaccinesCytokines cause inflammation when tissue is damaged or infectedCytokines are substances or structures that mediate specific reactions in body tissuesmedical staff eliminate inflammation caused by the virus by widely activating the body's natural inflammatory removal activitiesimage source: NIAID", "We now recognize the importance of controlling this powerful inflammatory response in COVID-19 infections to reduce associated organ damage and mortality," said Gilligan, a medical student"Finding new ways to inhibit the body's inflammatory response to COVID-19 may be as important as finding effective antiviral therapy to control COVID-19 infection and reduce life-threatening organ damageGilligan said: "In addition, these compounds have been found to be non-toxic and immune-suppressing in ongoingclinical trials of other inflammatory diseases, making them more likely to be used for rapid clinical transformation"
the study found that a marker ofSARS-CoV-2 infection is a cytokine storm, which is caused by a sharp increase in cytokines produced by immune cells; SARS-CoV-2 causes unsuppressible inflammation that can lead to widespread organ damage, such as lung failure; and current COVID-19 treatment strategies focus on suppressing individual pro-inflammatory cytokines rather than widespreadly inhibiting the body's inflammatory response; and lipid-mediated factors extracted from omega-3 fatty acids can be used as natural signals of inflammationincreasing the levels of these lipid-mediated factors in the body may be a new treatment that can prevent life-threatening inflammation caused by SARS-CoV-2"We're excited that these lipid-mediated factors that can 'shut down' or dissolve inflammation have been used inclinical trialsfor other inflammatory-driven diseases such as eye disease, periodontal disease, and pain," said Dipak Panigrahy, an assistant professor of pathology at theBess Israel DeaconSagency Medical CenterThese mediated factors can be quickly used to turn off inflammation in patients with COVID-19(biovalleybioon.com)References:A new to averting caused by COVID-19
Dipak Panigrahy et al,: resolution-pronged approach to averifin cytokine storms in COVID-19,Cancer and Metastas Reviewis (2020)DOI: 10.1007/s10555-020-09889-4