Shenzhen Institute of advanced technology, Chinese Academy of Sciences: ultrasound administration or reversal of multidrug resistance

On December 17, the reporter learned from Shenzhen Institute of advanced technology of Chinese Academy of Sciences that Zheng Hailong's research group of the Institute of medical engineering of Chinese Academy of Sciences explored the reversal effect and mechanism of doxorubicin, a chemotherapy drug carried by liposome microbubble complex, on multidrug-resistant breast cancer under the stimulation of ultrasound, and made progress The relevant results were published online in the Journal of controlled release This study is of great value for the development of new ultrasonic drug delivery and treatment technology The results show that the drug loaded microbubble complex combined with ultrasound can enhance the uptake of adriamycin, promote the rapid entry of drugs into the nucleus and reduce the drug efflux, so as to enhance the killing activity of adriamycin on drug-resistant breast cancer cells Further mechanism study found that drug loaded microbubble complex combined with ultrasound can significantly improve the level of oxygen free radicals and reduce the expression of P-glycoprotein, thus enhancing the level of DNA damage and apoptosis of drug-resistant cells Chemotherapy is an important means to treat tumor However, multidrug resistance of tumor cells to chemotherapy drugs is one of the main reasons for the failure of chemotherapy P-glycoprotein is over expressed on the surface of many MDR tumor cells, which can expel many anticancer drugs with different structures and functions out of the cell and reduce the concentration of effective drugs in the cell Therefore, eluding the role of P-glycoprotein is an important way to overcome the drug resistance of tumor cells.