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Shanghai Jiaotong University Zhao Yilei's team found that a novel sulfur bond of sulfur-modified DNA has special significance in iodine cleavage reaction and SBD protein recognition

 Last Update: 2022-05-18
 Source: Internet
 Author: User

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Recently, the comprehensive authoritative magazine "Proceedings of the National Academy of Sciences of the United States of America" and the professional journal of physical chemistry "Physical Chemistry Chemical Physics" published the professor of Shanghai Jiaotong University School of Life Science and Technology and State Key Laboratory of Microbial Metabolism.

In the PNAS paper, Dr.

The iodide cleavage reaction is highly sensitive to DNA phosphorothioation modification sites, and is widely used in DNA gel electrophoresis detection, deep sequencing and single-molecule sequencing of sulfur-modified bacteria

In vivo, sulfur-modified DNA achieves special physiological functions such as epigenetic regulation and restriction modification by interacting with proteins

This work was funded by the National Key R&D Program, the General Program of the Natural Science Foundation of China, and the International Cooperation Joint Laboratory of Metabolism and Developmental Sciences of the Ministry of Education

Paper link:

https:// href="https://doi.

author:

School of Life Science and Technology

Contributing unit:

School of Life Science and Technology

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