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    Home > Biochemistry News > Biotechnology News > Shanghai Jiaotong University Professor Wang Hui and other teams discovered a new mechanism for cadmium exposure to promote body fat accumulation

    Shanghai Jiaotong University Professor Wang Hui and other teams discovered a new mechanism for cadmium exposure to promote body fat accumulation

    • Last Update: 2021-11-15
    • Source: Internet
    • Author: User
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    A few days ago, the internationally renowned environmental science journal Journal of Hazardous Materials published an online publication titled "Cadmium accelerates bacterial oleic acid production to promote" "fat accumulation in Caenorhabditis elegans"
    .


    This work uses Caenorhabditis elegans and a bacterial culture system to study the relationship between environmental pollutants, bacteria and hosts, and found that environmental low-dose cadmium exposure promotes the body’s fat accumulation by up-regulating the content of the metabolite oleic acid in bacteria.


    Cadmium is a widespread environmental pollutant that can accumulate in the human body through dietary intake and cause various health hazards such as metabolic diseases
    .


    The half-life of cadmium in the human body is about 10-30 years.


    In this study, the researchers found that low-dose exposure to cadmium can significantly promote the accumulation of fat in nematodes, and using the Caenorhabditis elegans-E.
    coli culture model, established different systems such as normal, inactive bacterial metabolism and aseptic culture, which proved Bacterial metabolism plays an important role in the toxicity of cadmium in accumulating fat accumulation in nematodes
    .


    Further studies have found that low-dose exposure to cadmium significantly increases the production of the bacterial metabolite oleic acid, and the increase in the level of oleic acid in the bacteria can further promote the fat content of the host nematode.


    Ma Xueqi, a Ph.


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