Shanghai Jiao Tong University has made new progress in the research of multidirectional growth regulation of neural stem cells

Figure Schematic diagram of nanobrushing technology and the directional regulation effect of this technology on neural stem cells

With the support of the National Natural Science Foundation of China (approval numbers: 82071042, 81720108010, 51873033), the research group of Professor Li Chunyan and Yin Shankai of the Department of Otolaryngology, Head and Neck Surgery, Shanghai Jiao Tong University School of Medicine, and Professor Wang Hongzhi's research group of the School of Materials Science and Engineering of Donghua University have made new progress
in the directional arrangement of one-dimensional nanostructures and the regulation of neural stem cell growth 。 The related research results are "A nanobrush-shearing strategy enabling the alignment of 1D nanomaterials for synchronous electrochromic actuators and controlled.
" growth of neural stem cells" published online in the journal
Materials Today Nano.
Links to papers: https://doi.
org/10.
1016/j.
mtnano.
2022.
100256
.

Directed growth of neural stem cells is essential
in nerve regeneration and repair.
The currently reported neural scaffolds are difficult to achieve multidirectional regulation
of cells in the two-dimensional plane.
In this study, a new nanobrush coating process
was developed by improving the traditional Chinese brush coating technology and designing the shear mechanics.
This method realizes a variety of patterned arrangements of various one-dimensional nanostructures (such as silver nanowires, transition metal oxide nanowires, etc.
) on the substrate
.
The team further used this nanotopology to successfully induce the growth patterns of proliferating and differentiated neural stem cells to form unidirectional and cross-direction growth patterns on the substrate without affecting the activity of neural stem cells (Fig).

This study breaks through the application limitations of the nanobrush coating process and will provide a simple and easy new strategy
for directional tissue repair of microscopic modified neural scaffolds.