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Servier mutant IDH1/2 enzyme dual inhibitor vorasidenib shows efficacy

 Last Update: 2021-08-12
 Source: Internet
 Author: User

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Servier recently announced that the results of a phase 1 dose-escalation clinical study (NCT02481154) evaluating vorasidenib as a single agent for the treatment of isocitrate dehydrogenase (IDH) mutant advanced solid tumors (including low-grade gliomas, LGG) have been published In the famous international cancer research journal "Clinical Cancer Research"

In the first human study (NCT02481154), a total of 93 patients with advanced solid tumors with IDH1/2 mutations were enrolled, including 52 patients with gliomas

The results showed that vorasidenib showed good safety at a once-daily dose of <100 mg, and showed preliminary clinical activity in patients with relapsed or progressive IDH1/2 mutations in low-grade gliomas

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