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| Scientists reveal the scientific mechanism of mammals "shocked" |
Research byProfessor Xiong Wei's group from the University of Science and Technology of China found that the neural loop of the cochlear nucleus-pontine reticular nucleus-spinal cord motor neurons plays an important role in the "shock" response of mammals
.
This discovery deepens the understanding of the neural mechanism of instinctive defense behavior, and provides a new direction for the follow-up study of abnormal startle reflex behaviors in human post-traumatic stress disorder, panic disorder and other diseases
The research of Xiong Wei's group found that the neural circuit of the cochlear nucleus-pontine reticular nucleus-spinal cord motor neurons plays an important role in the "shock" response of mammals
The research of Xiong Wei's group found that when sound induces the startle reflex, glutamatergic neurons located in the reticular nucleus of the pontine caudal side of the brainstem of mammals are activated in large numbers
.
Using optogenetic and chemical genetic methods, the researchers found that specific "activated neurons" can induce bounce performance in mice, and the muscles of the neck and hind limbs can also simultaneously record myoelectric activity, which is a typical startle reflex behavior
Subsequently, the research team found that glutamatergic neurons directly receive excitatory projections from the cochlear nucleus and have a direct synaptic connection with spinal cord motor neurons through virus tracing
.
Their further experimental results showed that after receiving input from the cochlear nucleus, glutamatergic neurons project directly to spinal cord motor neurons, and finally complete the control of the muscles of the neck and limbs
Related paper information: https://doi.
https://doi.
org/10.
1038/s41467-021-26723-9 https://doi.
org/10.
1038/s41467-021-26723-9
