-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Nonalcoholic fatty liver disease (NAFLD), commonly known as fatty liver disease, is an epidemic that often occurs in obese people
The liver is an important organ that coordinates the body's overall glucose and fat metabolism
To answer this question, Chan's team examined gene expression in the livers of high-fat diet-induced obese mice and found that a protein -- SH3 domain-binding kinase (SBK1) -- was elevated only in the livers of obese mice
Chan's team discovered for the first time that fatty acid accumulation induces SBK1 expression in mouse liver
Chan's team found that the SBK1 protein is a protective factor against excessive lipid accumulation
In addition to animal studies, Chan's team used in vitro cell models to answer the question of how the SBK1 gene controls lipid metabolism in the liver
To extend their findings to therapeutics, Chan's team further tested whether manipulating SBK1 protein activity in the liver could rescue the damaging effects of obesity
Note: The original text has been deleted
References:
1.
2.
https://medicalxpress.
