Scientists illustrate the key role of alkaline granulocytes in lung development!

Adults' lungs are made up of many highly specific cell types that are protected by a variety of immune cells, so how do these immune cells migrate to the lungs after birth and during development? How do these cells affect each other? In a recent study published in the international journal Cell, scientists from the Medical University of Vienna and others used advanced single-cell sequencing techniques to clarify the underlying molecular mechanisms involved, and found that basophils, known as immune cells in allergic reactions, may play a key role in macrophage development in the lungs, and that the findings could help researchers develop new clinical strategies to fight lung disease.
The lungs are important organs for the body to ingest oxygen to exchange carbon dioxide, but researchers often underestimate the enormous complexity of the lungs, where a large group of heterogeneous cells work closely together to ensure normal function of the lungs, as well as critical gas exchanges, which contain a large number of immune cells that effectively prevent invasive microorganisms outside the body and transplant effective inflammatory responses.
Currently, researchers don't know the development and maturation mechanisms of complex organs during embryonic development and after birth, and in this study, researchers used a combination of high-volume single-cell RNA sequencing, functional analysis, and cutting-edge microscopic techniques to gain an in-depth understanding of the developmental mechanisms of the lung immune system, while the researchers graphed the first comprehensive map of cell types and the interconnected cell lines within them during lung development.
the researchers point out that alkaline granulocytes are special immune cells in the lungs responsible for allergic reactions that develop into special cell subtypes and produce key growth factors and cytokines that are not the same as the alkaline granulocytes circulating in the blood previously described by the researchers, who had not previously known the key role of such cells in the development and dynamic balance of the body's organs, especially the lungs.
researcher Dr Anna-Dorothea Gorki says lung development is often carried out in waves, and the alkaline granulocytes inherent in the lungs are important "players" who interact extensively with other types of cells in the lungs, especially macrophages;
Finally, the researchers say that from a medical point of view, the findings are interesting, and that the specific signals of alkaline granulocytes and their effects on macrophages may suggest that they play a key role in the development of lung disease, which is critical for later researchers to develop new treatments to treat a variety of lung diseases. (Bio Valley)