Scientists are expected to develop new anti-cancer therapies that have no damaging effect on healthy cells

Medicines Network, Aug13 (Xinhua) -- In a study published in the international journal Journal of Bio Chemicalry, scientists from Oregon State University are looking to develop a new type of effective cancer therapy that has no damaging effect on healthy cellsPHOTO SOURCE: MACA FRANCO, OSU COLLEGE OF SCIENCE
Depending on the type of cancer and therapy, patients are often affected by side effects of the treatment, including anemia, loss of appetite, bleeding, constipation, and diarrhea, and when researchers studied type 2 neurofibromatosis (NF2), they found special protein modifications, the main characteristic son of NF2 is theoftumors in the nervous system, i.ethe production of Shwang's cell tumorResearcher Maca Franco says the main sign of tumor cell behavior is that the cells grow out of control, and that tumor cells need to continuously generate energy and replicate using basic componentsresearchers say Xuwang's cell tumor cells are capable of producing oxidants, nitrifications and peroxanoidns, which modify the tyrosine in the protein, and when tyrosine in a particular protein is nitrosified, the effect reprogrammes the metabolism of tumor cells to promote their proliferation, said Franco, who said that in order to maintain sustained growth, tumor cells must changeThe way in which energy and basic components are produced is to exhibit a metabolic phenotype that is different from normal cells; the powerful oxidant produced by the cells, peroxidal nitrite, controls the metabolic changes in tumor cells in the nervous system and supports their growth; and the researchers believe that when special proteins are nitited, they gain new features that are not previously available, and that these functions may control tumor growthperoxade nitrite sepsis in pathological conditions, such as in tumor tissue, but this does not occur in normal tissuesThe results of this paper show that the production of peroxamate in targeted tumor cells may be expected to help develop new strategies for treating nervous system tumors without side effects on normal tissuesoriginal origins:Jeanine CPestoni, Stephani Klingeman Plati, Oliver DValdivia Camacho, et al Peroxynitrite support sia di'r reprogramming in merlin-deficient Schwann cells and promotes cell survival, JBCJune 6, 2019, doi:10.1074/jbc RA118.007152