Scientists have made new progress in the field of cancer metastasis!

This article has compiled several important research results to focus on the new advances scientists have made in cancer metastasis research and share them with you! File photo: Wikipedia 1 Nat Cancer: Scientists find special genetic markers that promote prostate cancer metastasis or are expected to help develop new individualized anticancer therapies doi:10.1038/s43018-020 In a study published in the international journal Nature Cancer, scientists from Rutgers University and other institutions in the United States found that genetic markers in the human body may be able to promote metastatic prostate cancer through synergy.
the study, researchers studied prostate cancer cells from humans and mice and found a set of 16 genes that can cause cancer metastasis, which often brings great difficulties and challenges to treatment. the genetic markers identified by
researchers can help predict whether prostate cancer patients are more likely to have cancer metastasis, including bone metastasis, which is the second leading cause of cancer-related death in U.S. men, and can maintain a five-year survival rate of almost 100 if diagnosed early. % of patients with metastatic prostate cancer have a 5-year survival rate of only 30 per cent; current treatments such as first- and new-generation targeted androgen therapy, radiotherapy, chemotherapy, etc. may not always be effective, and it is not possible to predict which patients are at risk of developing the disease to a malignant stage.
read in the Journal of Science! Uncover the mysterious link between obesity and cancer metastasis! Doi:10.1126/sciadv.abc3175, a study published in the international journal Science Advances entitled "Decellularized extracellular matrix scaffolding full of identify-length collagen VI as a driver of breast cancer of the invasion of obesity and metastasis" by scientists from Tufts University and other institutions revealed the link between obesity and cancer metastasis.
One in two men or one in three women will be diagnosed with cancer in their lifetime, but fortunately, scientists have made significant progress in treating multiple cancers, especially when the cancer is confined to a small area, allowing researchers to remove the lesions through surgical excision or chemotherapy.
In some patients, tumor cells move away from primary lesions and invade other areas of the body, known as cancer metastasis, which induces widespread damage to the patient's body and makes treatment difficult, in fact, 90 percent of cancer deaths are directly related to cancer metastasis.
The risk of cancer metastasis is particularly high in some populations, including those who are obese, and obesity appears to affect Black Americans and Hispanics more than the general population, and researchers don't yet know why obesity induces cancer metastasis at a higher rate.
: Scientists reveal a new molecular mechanism for metastatic prostate cancer doi:10.1038/s41467-020-18843-5 In a study published in the international journal Nature Communications, scientists from the University of Tampere and others revealed a Special mechanisms may help explain the metastasis of prostate cancer, which occurs when tumors develop in prostate cancer and produce multiple spatially mixed cancer cell clones that may attack organs around the prostate, however, only one dominant cell clone can systematically spread and metasnat in the body, and new subcellular clones may produce and mediate the constant metastasis of cancer cells during metastasis.
researchers also found that the spread or spread of the disease may vary from patient to patient, and that genetic drivers that occur in cancer cell cloning may help effectively distinguish between those cell subclonals that spread throughout the body and which subclonals are confined to each patient's prostate.
this paper, researchers analyzed samples from 10 prostate cancer patients from diagnosis to death from metastatic disease.
In this study, researchers performed the first genome-evolutionary combination analysis of local and metastatic prostate cancer, and were able to detect these particular evolutionary signals from patients' blood and cerebrospinal fluids, such as biopsies; When cancer DNA is found, the cloning of the main cancer cells that connect the cancer metastatic lesions can be detected, and the detection of cancer cell subclonals is variable; it seems reasonable to use liquid living tissue tests to monitor metastatic prostate cancer, although it does not always perfectly reflect the condition in the patient's body, so researchers need to further improve and expand these findings.
( 4) Sci Trans Med: New study could block breast cancer cells from transferring doi to the brain: 10.1126/scitranslmed.aax2879 When breast cancer spreads to the brain, it can have severe consequences, usually with only six months of life.
clinical statistics show that women with HER2-positive breast cancer tend to have brain metastasis in up to 55% of cases.
for brain metastasis, chemotherapy drugs are often ineffective because they cannot cross the blood-brain barrier.
combination therapy for breast cancer tumors in the brains of mice can significantly reduce tumor size and improve survival, according to a new study.
about 75 percent of mice with breast cancer brain metastasis can be completely cured after treatment.
findings were published in the international journal Science Translational Medicine.
we have developed a new combination therapy that can cross the blood-brain barrier and significantly improve survival, according to researchers.
the two drugs are micro-tube protein inhibitor vinorelbine (approved by the U.S. Food and Drug Administration (FDA) for clinical use) and bromine inhibitor I-BET-762 (FDA approved for clinical trials).
inhibitors increase the expression of beta III-micro-tube proteins in brain metastasis breast cancer cells, which in turn can be selectively killed by vinorelbine.
Tumor cells living in complex micro-environments include extracellular substations (ECMs) and different types of normal and active cells, and in addition to soluble chemical signals, the mechanical properties of tumor micro-environments are also involved in tumor growth, invasion and metastasis, and changes in histological properties are usually made through changes Cell behavior predates and drives the progression of the disease, the increase in tissue hardness is a variety of solid tumor characteristics, including breast cancer, pancreatic cancer, tissue hardness is its ability to react to force to resist deformation, usually partially regulated by the interaction between interstitial cells and ECM, in the tumor microenvironment of interstitial cells, activated fibroblasts or fibroblasts are caused by substylological synthesis disorders caused by tissue hardening, in addition, Myofibroblasts are able to express high levels of a-SMA (a-smooth myocardial protein) and apply a higher level of contraction to reshape and harden ECM, which further stimulates the activity of myocardial fibroblasts through the mechanical conduction of the whole protein, thus forming a positive feedback circuit.
Cell: A group of special cells promotes cancer cell metastasis and evades the immune system