Scientists have found important regulatory factors for tumor immunosuppression

In a new study, Cheng Jinke Of Shanghai Jiao university's School of Basic Medicine identified SENP1, an important regulatory factor for tumor immunosuppression, and found that it alters tumor process by affecting the development and function of MDSC, and suggests its potential value in clinical treatment of tumors. The findings were published recently in Cancer Research.
is a major disease that seriously affects the health of human life. The immune system affects all aspects of the tumor, and a large number of tumor treatment options targeting the immune system enter clinical research and application. MDSC is the main cell type that produces immunosuppression, which amplifies and promotes tumor development under the guidance of tumor. Understanding the development and function of MDSC is of great clinical significance to relieve tumor immunosuppression and promote tumor immunotherapy.
"We found in tumor specimens that MDSC has very low SENP1 expression, and tumors can significantly reduce the expression of SENP1 in MDSC, suggesting that SENP1 may affect the development or function of MDSC." Cheng Jinke told China Science that the researchers demonstrated that the missing MDSC of SENP1 has greater amplification, immunosuppression and tumor-boosting ability by knocking out SENP1 in mice. It is important to note that SENP1 deficiency does not affect the development and function of other immune cells, i.e. the effects of SENP1 on MDSC are cell-specific.
Cheng Jinke said that SENP1 as a tumor-MDSC immunosuppressive loop of the key regulatory factors have important clinical significance.
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