Scientists have for the first time analyzed molecular maps of retinal aging in humans and rhesus monkeys

Recently, Xue Tian Of the University of Science and Technology of China, in collaboration with scientists from Beijing Normal University and the
Institute of Biophysics, "drawn" the molecular map of retinal aging molecules of human and non-human primates for the first time in the world, and found that the cellular composition and key molecular characteristics of the human retina in the aging process. The results, published online August 25 in the National Science Review, provide potential intervention targets for delaying retinal aging and provide new ideas for the effective prevention and treatment of age-related retinal diseases.
is the most important perception of humans and animals, at least 80% of the external information is received, processed and perceived through the visual system. Light actes on photoreceptual cells in the retina, which convert light signals into electrical signals, pass through multiple neurons, and finally the visual signals are transmitted to the brain through the optic nerve, allowing humans and animals to perceive the size, light and dark, color, and movement of external objects. However, as we age, retinal function degrades. Therefore, understanding the cellular composition and changes of its intrinsic gene regulation network in the process of retinal aging can not be ignored in the treatment and prevention of age-related retinal diseases.
a total of 119,520 people of different ages and rhesus monkey retinal single-cell transcription group data collected by the Joint Team of China University of Science and Cymcote. By comparing the retinal cell composition and regional molecular differences between humans and rhesus monkeys, the researchers found that the homogenized retinal cells in the original boundary could actually be divided into two types of MYO9A-positive and negative cells, which make up a very different proportion between humans and rhesus monkeys;
To study the molecular evolution of retinal aging in humans and rhesus monkeys, the researchers fitted data on the retinal macular and outer periter regions to calculate the aging curves in both regions. The results showed that the degree of aging in the macular region was higher than that in the outer pervese region, which was consistent with the gene with neuropulation function expressed by the high expression of Muller glial cells in the outer region, and the damage of the optic rod cells was obvious in the aging process, especially the easier reduction of the number of myO9A gene-negative view rod cells in the aging process. The researchers also found that genes specific to macular regions showed a significant decrease in expression during aging, while genes with exoded regions did not decrease significantly. Finally, based on the retinal gene expression spectrum of the two species, the researchers constructed an expression map of 55 retinal disease susceptible genes and found that the regions and cell types expressed by these genes were specific. (Source: Gui Yunan Yangfan, China Science Journal)
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