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Neurodegenerative diseases are diseases of the central nervous system that cause dysfunction in the body due to the loss of neurons or their myelin, including traumatic brain or spinal cord injury (SCI), multiple sclerosis, and motor neurone disease.
because of the poor regenerative capacity of the central nervous system, its injury rehabilitation is currently an international medical problem.
Recently, researchers at Ohio State University's Institute of Neuroscience published their findings in the journal Nature Immunology, "A new neutrophilset promotes CNS neuron survival and axon regeneration", which found a new type of immune cell that not only saves damaged nerve cells from death, but also regenerates and repairs damaged nerve cells.
, the researchers identified human immune cell linees with similar characteristics that promote nervous system repair.
study, the researchers found a new type of granulocyte that has the characteristics of immature nemetic granulocytes, but has neuro-protection and neuroregenerative properties.
injecting these cells into mice with optic nerve damage or spinal cord nerve fiber damage can promote neuron survival and regeneration of retinal nerve cell axons.
this effect is achieved in part by secreting neurogrowth factors (NGF) and insulin-like growth factors (IGF-1).
, the researchers tested the ability of human bone marrow cells with immature neutral granulocyte characteristics to initiate nerve repair.
the transfer of these cells to the eyes of visually impaired mice with defective RAG1 genes directly stimulated the growth of fractured optic nerve cell axons.
Benjamin Segal, co-author of the study and a professor at Ohio State University's Institute of Neuroscience, said: "This growth factor secreted by the immune cell subteum enhances the survival of post-traumatic nerve cells in the central nervous system and stimulates the regeneration of broken nerve fibers in the central nervous system, which is truly unprecedented."
, the researchers will continue to explore the cells and amplification them in the lab to enhance the therapeutic effect.
hope that in the future these cells will help patients slow or stop the decline of sexual neurologic function.
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