Scientists have discovered a new model of phospholipids regulating the fate of pot stem cells

Liu Xingguo, a researcher at the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences, found that phospholipids regulate the fate of popotent stem cells in a new "tinge" model, revealing that phospholipids are not transported through membranes, but through signals to regulate the fate of cells, providing a new perspective and theoretical basis for the study of the function of lipid metabolism in the ability to obtain, maintain and lose lmucose stem cells. The study was published online Nov. 28 in Science Advances.according to
, the study found that phospholipids play a dynamic remodeling function in the process of reprogramming somatic cells to induce popotential stem cells (iPSCs), and identified phosphatidylethanolamine as a key lipid molecule in multipotential access and maintenance, which is the key event of reprogramming through signal transduction regulation "interstitial-supersethic conversion (MET).
phospholipids are the highest levels of lipids in most mammalian cells, not only as the main structural components of cytocyte membranes and organe membranes, but also involved in regulating many physiological pathological processes. Phospholipids are essential for the normal growth and development of mouse embryos, and knocking out multiple genes produced by phospholipids in mice, such as Chk alpha, Pcyt1, Pcyt2, etc., can lead to the death of their embryos. However, it is still not clear whether and how phospholipids regulate the maintenance, loss and obtainability of pots, and the specific role of phospholipids still needs to be answered.
researchers used high-precision, high-coverage lipid histology to detect the composition of phospholipids at different points in the reprogramming of body cells, and found a variety of dynamic changes in the reprogramming process. Among them, phosphatidylethanolamine suddenly rises and then decreases in the early stages of reprogramming, suggesting that it may play a key role in the early stages of reprogramming. This elevation is achieved through the CDP-ethanolamine approach, which facilitates the reprogramming of somatic cells to induce erythmatic stem cells. Through further mechanism research, the team found that phosphatidylethanolamine in reprogramming did not affect autophagy isometrial transport events, but by promoting the interaction of its binding protein Pebp1 and IKK alpha/β, inhibited PHOSORY of IKK alpha/β and the nucleation of NF-B, thereby inhibiting the expression of intercharge-related genes, to promote intersuperment-epithelyl conversion." In the aspect of multi-energy maintenance, phosphatidylethanolamine also has the function of regulating the growth of embryonic stem cells.
Liu Xingguo, a professor of cytosteal membranes, and cytogenetic membranes, like the walls of cells, separate the cells into several relatively independent spaces. Phospholipids, as membrane parts, are generally thought to affect cell fate through dynamics. However, as the Great Wall such a wall, in addition to the basic functions, can also assume the "tinge" such as signaling function, the study found that the cell membrane parts play a "thousands of miles to see wolf smoke" signaling role, directly to the nuclei of the cell "operation of the military account", through gene expression to achieve the transformation of cell morphology. Importantly, this new pattern of cell metabolism that regulates cell morphological changes is linked to phospholipids, cell migration, and cell fate. Because "intersupplation-skin conversion" is not only necessary in developmental differentiation, but also play an important role in tumor metastasis, this work provides a new way of thinking for exploring the physiological regulation of cell fate and the pathological regulation of cancer. (Source: China Science Journal Zhu Hanbin Miao Yu)
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