Scientists find sources of knowledge of heat and heat to help develop drugs

U.Sresearchers say nerves that feel cold or breezy are ordered by a proteinThis gives us a new understanding of the coldPrevious studies have shown that there is a type of nerve cell that specializes in cold-sensitive nerve cells: some of which detect a nasty sense of coldness, and others that perceive a more pleasant sensationResearchers at southern California universities found that most cold-sensitive nerve cells use a protein known as TRPM8, which can sense multiple sensations, Reuters reported"We all know that when we freezeour teethtremble, we have a distinct sense of cold," says McMee, whose team's work is published in the International Journal of Neurologyother research groups attributed the cold sensation to two different cold sensory nerve cellsOne idea, says McMee, is that there are nerve cells called cool fibers, and some are nerve cells with cold painScientists have long found that irritating substances such as menthol can stir up "cold"psychologicalphysical sensationsBut at the time, scientists had not yet worked out how the nervous system felt the change in external temperatureAfter studying mice, the researchers found that TRPM8 is a membrane protein, also known as ion channelsWhen the outside temperature drops to2
6 degrees Celsius
the membrane protein automatically turns on the , allows the ions to enter the , and activates the sensory nerve fibers Finally, , the brain receives signals about temperature changes from nerve fibers , humans seem to have the same mechanism The researchers studied cold-sensitive nerve cells to master the molecular mechanisms of sensation, which could help develop effective pain-relieving drugs