Scientists find a mechanism that allows cancer cells to 'self-destruct'

If cancer cells can self-destruct without harming healthy cells, then this will bring important implications for the treatment of cancer.
now, scientists have discovered a mechanism that might be able to achieve this goal.
, researchers at Tel Aviv University (TAU) in Israel revealed the key role of three proteins in killing cancer cells in the journal Oncotarget.
led by Professor Malka Cohen-Armon of the TAU School of Medicine, they found that these proteins can be specifically modified during cell filamentation, releasing an inherent "death mechanism" that eradicates cancer cell self-replication and is validated in a variety of tumor cells, including breast cancer, lung cancer, ovarian cancer, colorectal cancer, pancreatic cancer, blood cancer, brain cancer, and more. Professor Cohen-Armon,
, says the mechanism kills cancer cells without harming healthy cells.
according to this mechanism, the faster cancer cells multiply, the faster and more efficiently they are eradicated. the mechanism that
releases during fission may be applicable to invasive tumors that are not affected by conventional chemotherapy.
newly discovered mechanism involves modification of specific proteins that affect the structure and stability of the spindle body.
researchers have found that certain compounds, such as fisyl derivatives, can weaken the activity of these proteins, deform the structure of the spindle body and prevent chromosomal separation.
once these proteins are modified, cell isolation is stopped, accelerating the cell's self-destruction.
this mechanism may become a new target for cancer research.
researchers say the study was tested using fibulin derivatives, but other drugs that modify these proteins could also be used to destroy cancer cells.
researchers tested cultured cancer cells and mice implanted in human cancer cells, and used biochemical, molecular biology and imaging techniques to observe the mechanism.
in mice with triple-negative breast cancer cells, they observed stagnant tumor growth. "The identification mechanism and the disclosure of its relevance to tumor therapy open up new avenues for the elimination of malignant tumors," said Professor Cohen-Armon,
.
are currently exploring the potential of phystol derivatives to treat pancreatic and triple-negative breast cancers.
Source: Decoding Medicine.