Scientists discover cross-border 'butterfly effect' of cell fate regulation

The "observation group- metabolic group - metabolic group" cross-border "butterfly effect
The study was published online August 24 in Nature-Metabolism.
induced erythrogenic stem cell (iPSC) technology provides broad prospects for the study of human disease pathology and regenerative medicine treatment, and is also a good model for studying the transformation of cell fate. The iPSC reprogramming process is widely studied at different levels, including the surface level, transcription level, metabolic level and cellular level. However, whether and how to "cross-border" the fate of stem cells at multiple levels in reprogramming is a basic scientific question that has not been answered.
researchers proposed a new concept of cross-border cascading reactions of the "ombolic group-metabolic group-observational group" regulating the fate of omnicial stem cells by the matrilineal transcription factor Glis1, which shows the powerful function of Glis1 in reprogramming and stabilizing the genome of senescies cells, revealing the powerful function of Glis 1 In the cascading reaction of "observation group-metabolic group-observational group", the histoprotein acetylation and lactic acidification modification driven by the glycolytic metabolic group played the central role of "the stone of the mountain" in the pre- and later-stage observational genetic group connections.
liu Xingguo, the study looked at Glis1, known as the Yamanaka fifth factor, a matrihood transcription factor expressed only in eggs and fertilized eggs. The researchers first found that Glis1 not only promotes normal cell reprogramming, but also enables reprogramming of senescing cells. Further findings are that the iPSC genome obtained by Glis1 is more stable. These suggest that Glis1 is a powerful cell fate determining factor.
researchers analyzed and summarized the unique 3 unique glis1 mediated multi-ernomics obtained by using multi-group techniques such as chromatin immuno-precipitation sequencing and transcription group sequencing, targeted metabolite histology, chromatin open sequencing, etc. Stage approach - "Esogroup - Metabolic Group - Esogroup" cross-border cascading reaction:
This study puts forward the concept of cross-border cascading reaction of "esogroup-metabolic group-esogroup" regulated by cell fate, which has a wide range of physiological pathological significance. Glis1 is expressed not only highly in maternal cells, but also in pathological conditions such as cancer cells, so this cross-border cascading reaction has potentially important pathological significance. Importantly, this concept is applicable to many factors and provides a new theoretical basis for physiological regulation and pathological discovery of cells and development.
It is understood that the researchers vividly likened the cross-border cascade reaction to the "butterfly effect": the transcription factor Glis1 is like a butterfly-like breeze, triggering a genome-wide level of ploscopic tornadoes, this "butterfly effect", not only rely on the genome level can be completed, the need for "the stone of the mountain" - metabolic levels cross-border connection, the formation of the "metabolic group - metabolic group - esographic group" cascade reaction trilogy.
This cross-border cascade reaction, just as the "butterfly effect" in the breeze hurricane needs thousands of miles of chaotic conditions, and as the beauty of the blue porcelain in the pure green furnace fire needs small smoke and rain together to shape it. So many cells to return to old age and children, back to the sperm eggs "as first seen" multi-energy state, need to metabolize this cross-border volt pen.
, the study found that the new histoprotein lactic acid modification produced by lactic acid regulates cellular dryness. This is the first time this modification has been found to regulate cell conversion since histoprotein lactic acidification modification was discovered in macrophage polarization in October 2019. The discovery of Liu Xingguo's task force laid the foundation for this new direction. (Source: China Science Journal Zhu Hanbin Huang Boquan)
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