Scientists discover a new treatment for spinal injuries

　　MEDICAL NETWORK, Dec 20 (UPI) -- Researchers from the University of California, San Diego School of Medicine have discovered a new treatment for spinal injuries, according to a recent study In this study, the authors treated the state of the stem cells using an improved form of tissue-based lysozyme progenitor activator (tPA), a drug used to treat non-hemorrhagic stroke, and then injected it into rats with spinal injuries The results show that this treatment can significantly improve the effectiveness of stem cell therapy Their findings were published in the December 17, 2019 issue of Science Report tPA is used to break down blood clots and allow blood to flow more freely back to the brain after a stroke At the same time, tPA can also promote neuronal growth and inhibit inflammation As a result, the researchers used enzyme-free, active form of tPA, which still has anti-inflammatory and motor neuronal growth functions in the lab, the researchers added modified tPA to nerve progenitor cells (the precursors of neurons) After 15 minutes, the researchers injected tPA-treated or untreated nerve progenitor cells into a mouse model with severe spinal cord injury Two months after treatment, the researchers found that tPA treated 2.5 times more neuroprogenator cells than untreated cells Moreover, the cells processed by tPA have begun to differentiate into mature neurons she said: "It is amazing that over the period of two and four months, the ability of these progenitorcells to survive in the damaged cavity has improved dramatically "In past studies, it has been very difficult to keep these cells alive More surprisingly, it turns out that the rat's capacity tripled after four months of treatment the team plans to delve further into the precise role of improved tPA at the molecular level of nerve progenitor cells that stimulatetheir growth and help repair spinal cord injuries source: Stroke drug boot cell cell therapy for pinal cord injury in rat