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Fudan University
scientists led an international team of researchers who made important progress in the study of ADHD and sleep disorder co-disease, found brain imaging evidence of early ADHD symptoms causing post-sleep problems, and prompted the relevant molecular biology processes. The findings were published online in the journal Biopsychotics.ADHD has a higher proportion in children, often accompanied by sleep disorders, which also negatively affects the development of the nervous system. To clarify the causal relationship between ADHD and sleep problems, the study used causal inferred statistical models to find that the more severe the symptoms of early ADHD, the more problems that lead to late sleep.On this basis, the team conducted a study of brain structure imaging and identified a number of key brain regions associated with ADHD symptoms and sleep problems, mainly in attention networks and wakefulness systems. In these brain regions, less gray matter is associated with more severe ADHD symptoms, which can lead to more sleep problems later in life. Gene transcriptomics analysis found that some special genes mainly involved in molecular biological processes such as circadian rhythms and nerve signal conduction were expressed more in the above-mentioned brain regions.The team further confirmed that ADHD symptoms significantly increase sleep problems in children, revealing the mechanisms of ADHD and sleep disorder. Dr Luo Qiang, one of the paper's co-authors, said: "More importantly, we have found genes and brain structures associated with this., director of fudan University's Institute of Brain Intelligence Science and Technology, said the findings could help develop and design new treatments for early-stage ADHD to reduce ADHD symptoms and sleep problems in patients. (
Science and Technology
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