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Chromosomal manipulation in live cells indicates that they are liquid
.
For the first time, researchers from the French National Centre for Scientific Research, the Institut Curie and the Sorbonne University succeeded in physically acting
on chromosomes in living cells.
When they are not in the division phase, chromosomes are liquid, although not completely liquid
.
Previously, chromosomes were extra-long DNA molecules that were described as entangled like loose spheres of yarn to form a kind of gel
.
To draw these conclusions, published in the journal Science, scientists from CNRS, the Curie Institute, and the Sorbonne University, in collaboration with scientists at MIT, work in the laboratories of nuclear dynamics, physical chemistry, cell biology, and cancer, attaching magnetic nanoparticles to a small fraction of the chromosomes of living cells
.
Through these experiments, scientists were able to see that the range of forces naturally exerted in the nucleus — such as copying DNA through enzymes — is enough to fundamentally alter the conformation of chromosomes
.
Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics” by? Veer I.
