Science: Why dust mites cause allergies and asthma may be the lack of such immune cells in our bodies.

House dust mites (HDM) are tiny organisms, such as the size of a needle tip, visible to the naked eye.it seems small, but it has great power - it is an important allergen for allergic diseases such as asthma, allergic dermatitis and eczema.it is claimed that there can be 100000 particles of mite waste and dead mites in 1 gram of dust.then, we all have immune cells. Why do some people have allergic symptoms and even asthma, while others are at peace? In a recent study published in the journal Science immunology, scientists from the La Jolla Institute of Immunology (LJI) provided a clue - they found a previously unknown T-cell subset that can control allergic immune responses and asthma from house dust mites and other possible allergens.DOI: 10.1126/ sciimmunol.aba6087 Specifically, the LJI team used single cell transcriptomics to accurately look at the genes and molecules produced by specific T cells to HDM allergens.they tested the cells of four groups of subjects: subjects with asthma and HDM allergy, subjects with asthma but without HDM allergy, subjects with HDM allergy only and healthy subjects.their analysis showed that a subset of helper T cells expressing TDM reactive cells, called interleukin (IL) - 9 Th2, was more common in the blood of subjects with HDM allergic asthma than those who were only allergic to HDM.further analysis showed that those il9-th2 cells were rich in a set of molecules / genes that increased the toxic potential of these cells.in other words, those specific T cells can kill other cells and cause inflammation.in contrast, the other type of T cells was more prominent in non allergic subjects.these T cells express "interferon response signal" and are rich in genes encoding trail proteins.trail may be important because it inhibits the activation of helper T cells.this finding may mean that people with this particular cell population may be less responsive to HDM allergens.this can provide clues to why some people develop allergies and asthma while others don't.Dr. gr é gory seumois, CO director of the new study, director and director of the LJI sequencing core, said the new cell population may be one of many unknown mechanisms, which explains why healthy people do not become inflamed when inhaled with allergens.if this inhibitory effect is confirmed by functional studies, there may be a way to enhance the activation of these T cells or induce their proliferation in asthmatic or allergic people, thus opening the door to acting on immune cells before the onset of allergy and asthma.end References: [1] scientists uncover immune cells that may lower airway energy and asthma risk. [2] immune cell subset discovered that may help to prevent allergy and ashma responses to house dust mites