Science Sub-journal: The therapeutic effect of malaria vaccine can be predicted based on molecular markers

2020 May 15 News / BioValley BIOON / --- according to a study ISGlobal, the front and rear of immune markers can predict the protective effect of the vaccine inducedThis study analyzed the malaria vaccine acceptance (Mosquirix or RTS), and another individual experimental malaria vaccine in gene expression in peripheral blood cellsThe results were published in "ScienceTranslationalMedicine" magazine, shows that strengthen the immune system before the vaccine can potentially increase vaccine efficacyMalaria remains a major public health problem in 2018 led to nearly 200 million cases, resulting in 40 million deathsThe main obstacle to the development of an effective vaccine against this complex parasite is the lack of protective immunity indicators as well as inadequate understanding of the basic mechanisms of such protection(Source: Www.pixabay.com)In this study, the research team will genomics technology combined with scientific data and artificial intelligence to identify predictable vaccine efficacy (or immunogenic ) molecular characteristicsThey compared the two vaccines: (i) Africa is a large-scale pilot implementation Mosquirix vaccine research, the vaccine may provide some protection; (ii) based on CPS Plasmodium falciparum sporozoites attenuated vaccine inoculation in adult volunteers with high efficacy, and one of the most promising vaccine candidates are similarresearchers used before and during the CPS immune white blood cells obtained from 24 adult volunteers there, and the white blood cells of 225 infants or children from three African countries took part in the Mosquirix3 clinical trialsComprehensive analysis of gene expression of white blood cells after immunization showed a molecular characteristics related to the protection of the two vaccinesMore surprisingly, the study also identified baseline characteristics associated with a protective effect (ie before immunization)ISGlobal researcher and lead author of the study, explains: "This shows that we can identify a lack of baseline characteristics of these individuals and give them a higher CPS vaccine dose, or just before the injection of the vaccine enhanced the immune system to improve its effectiveness "(bio Valley Bioon.com)information source:Molecularsignaturescanpredicttheefficacyofmalariavaccinesoriginal source:G.Moncunillelal, > "Antigen-stimulatedPBMCtranscriptionalprotectivesignaturesformalariaimmunization,"ScienceTranslationalMedicine(2020) .stm.sciencemag.org / lookup / doi / ..scitranslmed.aay8924