Science Sub-journal: Reveals fragile window into HIV reinfection after heterogeneous hematopoietic stem cell transplant

a May 18, 2020 News /BiovalleyBIOON / --- For the treatment of different types of leukemia, a number of HIV-infected patients in need of allogeneic hematopoietic stem cells in a
transplantIn the transplant process, the majority of immune cells in these patients will be eliminatedThen, hematopoietic stem cellsfrom healthy donors is used to replace the damaged bone marrow of a patient to restore their immune systemIn a new study, researchers from Germany, France, Spain, Belgium, Italy, the United Kingdom and the Netherlands gathered 16 patients during allogeneic hematopoietic stem cell
clinical, virological and immunologicaldata before and after transplantationThey observed that, despite the re-activation of HIV-specific T cells, but after allogeneic hematopoieticStem cell transplantation, T cell reconstitution is incompleteHigh immune activation period of time indicates the presence of "vulnerability window (windowofvulnerability)" HIV virus database re-sowingThese data may provide valuable clues to help others in similar situations, more generally provide clues to cure HIV infectionThe results of recent research published in the journal ScienceTranslationalMedicine thesis titled "VulnerabilitytoreservoirreseedingduetohighimmuneactivationafterallogeneichematopoieticstemcelltransplantationinindividualswithHIV-1"HIV (yellow) SEM image of infected T cells (red), images from NIAIDFirst author of the paper, DrJohannaEberhard said, "In the first few weeks after allogeneic hematopoietic stem cell transplant, the donor cells and patient cells are still co-exist, CD4 + T cells (helper T cells) were strongly activated this activation may promote HIV virus to reactivate, and in expanding CD4 + T cells in the donor sow again "
in France with Pakistan researchers cooperation de Institute, Dr Eberhard also found to produce after this period of time donor cells react against new HIV-specific T cell protein This suggests that the proliferation of donor cells in contact with the process to the HIV virus, and have learned to respond to them Dr Eberhard said it confirmed the existence of "vulnerability window", during this time, HIV infection of donor cells may occur Co-corresponding author Dr JulianSchulzezurWiesch paper says, "shows the results together with previous results that there is a window of vulnerability, which may explain why allogeneic hematopoietic stem cell transplantation may not be completely rid of the HIV virus , although the number of infected cells dramatically reduced after allogeneic hematopoietic stem cell transplantation , may require additional immunotherapy or gene therapy designed to achieve continuous, self-control of HIV infection "(biological a valley Bioon.com) references: 1.JohannaM.Eberhardetal VulnerabilitytoreservoirreseedingduetohighimmuneactivationafterallogeneichematopoieticstemcelltransplantationinindividualswithHIV-1 .ScienceTranslationalMedicine, 2020, doi: 10.1126 / scitranslmed.aay9355 2.Criticalwindowforre-infectionwithHIVafterstemcelltransplantation https://medicalxpress.com/news/2020-05-critical-window-re-infection-hiv-stem.html