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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Tiffany Guide: In the past 20 years, technological advances in many fields have enabled us to have a better understanding of the biological behavior of pediatric brain tumors
.
In particular, improvements in neuroimaging have enabled us to make early diagnosis and to be more certain of tumor recurrence and spread
.
Magnetic resonance imaging (MRI), positron emission tomography (PET), magnetoencephalography, diffusion tensor imaging and functional MRI allow us to map brain tumors with extraordinary accuracy
.
For neurosurgeons, operating microscopes, variable-angle neuroendoscopes, neuronavigation platforms, intraoperative MRI, intraoperative functional cortical positioning navigation, intraoperative evoked potentials, and high-resolution ultrasound improve the safety of neurosurgery And as a result, the survival rate of sick children has been increased
.
However, for people suffering from high-grade glioma, there is still no effective way to deal with it
.
Recently, scientists have discovered new clues for the treatment of glioma in their experiments and research.
.
.
Glioma itself is a malignant tumor in the skull.
Once a glioma forms, it will spread to the surrounding area and invade the original Normal nerve tissue, once its invasion range is too large, it will cause a variety of clinical symptoms in patients, light headache, dizziness, severe numbness and weakness, speech dysfunction, and even more In severe cases, the patient will become unconscious and eventually lead to death
.
Although current medicine has made considerable progress in the treatment of certain types of childhood cancers, for scientists and clinicians, there is still a lack of effective treatments for high-grade gliomas
.
30% to 60% of children suffering from brain tumors carry mutations in the H3F3A gene, which contains a coding model for histone H3.
3 that plays a particularly important role in chromatin structure
.
Scientists know that one of these mutations is H3.
3G34R/v, which means that the glycine amino acid that scientists usually observe at position 34 is replaced by arginine or valine
.
Now, an international research team led by the University of Michigan Health Roger Cancer Center has discovered a small molecule inhibitor that can inhibit tumor growth in this glioma animal model, and develop new and More effective treatment methods bring new hope
.
They published the results of this research in an article titled "Epigenetically defined therapeutic targeting in H3.
3G34R/V high-grade gliomas" in "Science Translational Medicine": University of Michigan Department of Pediatric Pathology Artificial Intelligence and Robert Glick Family The research professor and senior research author Sriram Venneti, MD, said: “Due to the lack of effective treatments, the prospects for treating this disease are still quite bleak
.
These tumors usually occur in slightly older teenagers, often between 10 and 10 years old.
Between the age of 18, compared to the more well-known and more popular other types of childhood gliomas, people in this age group are more likely to develop the aforementioned brain tumors caused by the H3F3A gene mutation
.
"By the first author, Neuroscience The research team led by graduate student Stefan Sweha conducted a detailed study on the epigenetic changes of tumors in this study.
They found that these epigenetic changes are not essentially permanent mutations in the DNA itself, but they affect cell acquisition and The way to read the DNA sequence
.
In the end, they found out what kind of transformation led to the increased secretion of a protein called LIF (a leukemia inhibitor); in turn, the LIF protein activates the STAT3 signaling pathway, which is related to many other types of cancers.
.
These scientific findings: In the H3.
3G34R/V glioma mouse model, a small molecule inhibitor of STAT3 called WP1066 can well inhibit tumor growth and greatly improve the survival time of mice
.
Venneti added: “This drug compound has the important property of being able to cross the blood-brain barrier.
This discovery is critical to the development of treatments for brain cancer.
At present, scientists and the medical community are working on the gliablasts of adult patients.
Tumors in clinical trials
.
Our goal is to use this compound in clinical trials in pediatric patients
.
"Reference: https://medicalxpress.
com/news/2021-10-clues-pediatric-brain-tumors-harboring .
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
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Tumor Research [Science Sub-Journal] Salt has the effect of inhibiting tumors ? Scientists explain unexpected discoveries for you through mouse experiments! Recommendation·Activity The 5th Symposium on Modern Clinical Molecular Diagnosis at the 3rd Shanghai International Cancer Conference
Please indicate the source for reprinting.
Author: Tiffany Guide: In the past 20 years, technological advances in many fields have enabled us to have a better understanding of the biological behavior of pediatric brain tumors
.
In particular, improvements in neuroimaging have enabled us to make early diagnosis and to be more certain of tumor recurrence and spread
.
Magnetic resonance imaging (MRI), positron emission tomography (PET), magnetoencephalography, diffusion tensor imaging and functional MRI allow us to map brain tumors with extraordinary accuracy
.
For neurosurgeons, operating microscopes, variable-angle neuroendoscopes, neuronavigation platforms, intraoperative MRI, intraoperative functional cortical positioning navigation, intraoperative evoked potentials, and high-resolution ultrasound improve the safety of neurosurgery And as a result, the survival rate of sick children has been increased
.
However, for people suffering from high-grade glioma, there is still no effective way to deal with it
.
Recently, scientists have discovered new clues for the treatment of glioma in their experiments and research.
.
.
Glioma itself is a malignant tumor in the skull.
Once a glioma forms, it will spread to the surrounding area and invade the original Normal nerve tissue, once its invasion range is too large, it will cause a variety of clinical symptoms in patients, light headache, dizziness, severe numbness and weakness, speech dysfunction, and even more In severe cases, the patient will become unconscious and eventually lead to death
.
Although current medicine has made considerable progress in the treatment of certain types of childhood cancers, for scientists and clinicians, there is still a lack of effective treatments for high-grade gliomas
.
30% to 60% of children suffering from brain tumors carry mutations in the H3F3A gene, which contains a coding model for histone H3.
3 that plays a particularly important role in chromatin structure
.
Scientists know that one of these mutations is H3.
3G34R/v, which means that the glycine amino acid that scientists usually observe at position 34 is replaced by arginine or valine
.
Now, an international research team led by the University of Michigan Health Roger Cancer Center has discovered a small molecule inhibitor that can inhibit tumor growth in this glioma animal model, and develop new and More effective treatment methods bring new hope
.
They published the results of this research in an article titled "Epigenetically defined therapeutic targeting in H3.
3G34R/V high-grade gliomas" in "Science Translational Medicine": University of Michigan Department of Pediatric Pathology Artificial Intelligence and Robert Glick Family The research professor and senior research author Sriram Venneti, MD, said: “Due to the lack of effective treatments, the prospects for treating this disease are still quite bleak
.
These tumors usually occur in slightly older teenagers, often between 10 and 10 years old.
Between the age of 18, compared to the more well-known and more popular other types of childhood gliomas, people in this age group are more likely to develop the aforementioned brain tumors caused by the H3F3A gene mutation
.
"By the first author, Neuroscience The research team led by graduate student Stefan Sweha conducted a detailed study on the epigenetic changes of tumors in this study.
They found that these epigenetic changes are not essentially permanent mutations in the DNA itself, but they affect cell acquisition and The way to read the DNA sequence
.
In the end, they found out what kind of transformation led to the increased secretion of a protein called LIF (a leukemia inhibitor); in turn, the LIF protein activates the STAT3 signaling pathway, which is related to many other types of cancers.
.
These scientific findings: In the H3.
3G34R/V glioma mouse model, a small molecule inhibitor of STAT3 called WP1066 can well inhibit tumor growth and greatly improve the survival time of mice
.
Venneti added: “This drug compound has the important property of being able to cross the blood-brain barrier.
This discovery is critical to the development of treatments for brain cancer.
At present, scientists and the medical community are working on the gliablasts of adult patients.
Tumors in clinical trials
.
Our goal is to use this compound in clinical trials in pediatric patients
.
"Reference: https://medicalxpress.
com/news/2021-10-clues-pediatric-brain-tumors-harboring .
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Popular·Article Diagnostic Test [The Lancet] Call for action! Nearly half of the world's people cannot get basic diagnosis for many common diseases.
Can the COVID-19 pandemic help change the diagnosis? Immunotherapy [Nature Sub-Journal] Lung epithelial cells control lung immunity? This will lay the foundation for the treatment of many lung diseases! Tumor Research 【Research】Be alert! Summarizing 30 years of big data: esophageal adenocarcinoma is showing a younger trend.
Medical trends [News] The Nobel Prize in Physiology or Medicine in 2021 was announced, and the pain receptors won! Intestinal health [PNAS] research has discovered the "second brain" that exists in the intestine, and its glial will open up new ways to treat intestinal diseases! Tumor Research [Nature Sub-Journal] The use of single-cell multi-omics to study tumor cells is a new idea, the Harvard Medical School and other top-level teams have created a precedent! Tumor research [Science] protein may become a new breakthrough in cancer treatment! New Coronavirus [Science] The truth about the source of SARS-CoV-2? The coronavirus that is the closest to the new coronavirus so far has been found in Lao bats, with a matching rate of 96.
8%! Coronavirus [The BMJ] In Israel, where the vaccination rate is 78%, why is the epidemic still out of control? Is there a need to worry about the effectiveness of the new crown vaccine? Is it necessary to strengthen the injection? Organoid Research [Nature Sub-Journal] A 3D pancreatic cancer tumor model cultivated by an international team of scientists including Shanghai Jiaotong University can effectively improve the treatment of pancreatic cancer.
Tumor Research [Science Sub-Journal] Salt has the effect of inhibiting tumors ? Scientists explain unexpected discoveries for you through mouse experiments! Recommendation·Activity The 5th Symposium on Modern Clinical Molecular Diagnosis at the 3rd Shanghai International Cancer Conference
