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For nearly a decade, scientists have known that HIV integrates itself into the genome of cells that may cause cancer
In a new study, researchers from the National Cancer Institute and the University of Pittsburgh School of Medicine pointed out that they discovered why doctors did not observe a higher incidence of T-cell lymphoma among HIV-infected people
When HIV enters the human body, it looks for T cells and inserts its genetic sequence into the cell’s DNA
Previous studies have found that HIV can insert itself into the genetic code of T cells, prompting these infected cells to grow into large, non-cancer clones.
The expression of two fusion mRNAs---STAT3-Tat and 3'LTR-STAT3---, pictures from Science Advances, 2021, doi:10.
These previous findings have created a paradox: if HIV can integrate into the oncogenes of T cells (genes involved in normal cell division, once mutated, it will cause cancer cells to grow), shouldn't it also cause lymphoma?
To answer this question, the authors obtained samples from 13 HIV patients with lymphoma and selected three samples with high levels of HIV provirus, indicating that this virus may be involved in the formation of cancer
They then explored these samples to understand where HIV inserted into the DNA of T cells
Due to advances in medicine and care, HIV-infected people live longer and therefore have more years to accumulate mutations in the host's genes
Note: The original text has been deleted
Reference materials:
John W.
