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The exchange of gas between the air we breathe and the blood is carried out through the alveoli, which are tiny air sacs
Surfactants are secreted continuously in the lungs, while alveolar macrophages (AM) break them down and clear
Professor Mildner, the corresponding author of the study, has been studying macrophages for 20 years
The key role of transcription factor C/EBPβ
Professor Alexander Mildner and Professor Achim Leutz chaired the study
The researchers isolated alveolar macrophages from healthy mice and mice lacking the C/EBPβ gene and performed in vitro analysis
An important mystery
Molecular analysis further showed that in mice lacking the C/EBPβ gene, another transcription factor, PPARg, was also downregulated
Alveolar protein deposition is the result of
Therefore, C/EBPβ appears to be a missing link
What are the keys to understanding other diseases?
Macrophages are scavengers of the immune system, but they do more than just remove bacteria and viruses
Abnormal lipid metabolism is not only the root cause of alveolar protein deposition; It can also cause atherosclerosis, a serious vascular disease
Professor Mildner said: "We believe that the signaling pathways we have revealed are also important
For alveolar proteinosis, a new treatment is about to emerge
Source text search
Dorothea Dörr et al.
