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Science: How do hungry cancer cells switch food sources?

 Last Update: 2022-09-20
 Source: Internet
 Author: User

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Cancer cells typically grow in low-nutrient environments, and to meet this challenge, they shift their metabolism into using protein as an alternative "food.

Amino acids are a component of proteins and are key nutrients

To better understand the molecular pathways of this nutrient transition in cancer, two groups of scientists with the same expertise collaborated: Wilhelm Palm of the German Cancer Research Center (DKFZ) in Heidelberg is a leading expert in cancer metabolism, and Johannes Zuber of the Vienna Institute of Molecular Pathology (IMP) brings a wealth of experience

Among these genes, the scientists found a featureless gene that is essential

The scientists then turned to mouse models to study the function of LYSET in real tumors

Wilhelm Palm's lab was one of the first to describe the ability of cancer cells to feed on extracellular proteins

"That's why this discovery is so exciting," Johannes Zuber said

Original link:

Catarina Pechincha, Sven Groessl, Robert Kalis, Melanie de Almeida, Andrea Zanotti, Marten Wittmann, Martin Schneider, Rafael P.

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