Science discovers the secret of the formation of intestinal organs

Our internal organs and all organs are arranged in a left-right asymmetrical pattern in the body so that everything fits
.

At the same time, the development of organs like the gut is by no means accidental
.

Now, a study published Sept.

These findings have important implications for understanding the basic mechanisms of organ formation, helping to diagnose and prevent birth defects such as poor bowel rotation and volatile, both of which can twist and suffocate
the developing intestine.

Natasha Kurpios, senior author of the study, said: "The whole gastrointestinal tract is a tube that absorbs all our nutrients, and it's huge, so it has to be looped
in our bodies.

"We found out years ago that the loop is highly conservative and very, very specific," Kurpios said
.

It turns out that the locations of organs such as the heart, liver, lungs, and intestines are all asymmetrical — on one side of the body, or across the left and right sides, but not in the
center.

Previous studies have shown that a gene called node induces the first wave of Pitx2 genes to establish an early body plan
.

The researchers found that a sensor called tgf-β lurks in the body until it is activated
by mechanical forces.

In this study, the researchers used engineered mouse and chicken embryos, which allowed Kurpios and colleagues to open a small window on the eggshell so they could observe development and manipulate gene expression
.

Professor Jan Lammerding of the Meinig School of Biomedical Engineering, a co-author of the study, used probes in living embryos to measure the hardness and elasticity
of the dorsal side of the mesentery.

essay

Pitx2 patterns an accelerator-brake mechanical feedback through latent TGFb to rotate the gut